Overall, the studies reviewed in this section demonstrate that diverse chemical scaffolds, particularly indoles, indazoles, hydrazones, phthalimides, indanones, and chalcones, have yielded highly potent and selective MAO-B inhibitors with favorable pharmacokinetic properties and neuroprotective effects, reinforcing the relevance of this isoform as a strategic target in the development of novel therapies for PD. The gene discussed is MAOB; the disease is Parkinson disease.