Taken together, in this section we highlighted the rational design of multifunctional and multitarget-directed compounds capable of inhibiting both MAOs in addition to concomitant modulation of other molecular targets, including cholinesterases, COMT, caspases, and adenosine and histamine receptors, aiming at neuroprotection in neurodegenerative diseases. This evidence concerns the gene BCHE and neurodegenerative disease.