In ALI rats, SLEL similarly reversed the LPS-induced upregulation of phosphorylation of PI3K (p < 0.05), Akt (p < 0.05), mTOR (p < 0.05), ERK (p < 0.05), P38 (p < 0.01), JNK (p < 0.05), IκBα (p < 0.01), and P65 (p < 0.01) (Figure 8N–U). Here, MAPK8 is linked to acute respiratory distress syndrome.