In a further experiment, utilizing a norepinephrine depletion model with fusaric acid, a dose-dependent reversal of anxiety-related behavior was observed with the administration of glycyrrhizin, which was also accompanied by an increase in brain metabolic signs (increase in adenosine triphosphate (ATP)) and integrity (increase in brain-derived neurotrophic factor, BDNF) [265]. This evidence concerns the gene BDNF and Anxiety.