Similarly, co-ultramicronized palmitoylethanolamide combined with the flavonoid luteolin effectively alleviated both social and non-social deficits in a murine autism model by modulating TNFα and IL-1β, reducing GFAP and NF-κB expression, and enhancing hippocampal neurogenesis and neuroplasticity [125]. The gene discussed is TNF; the disease is autism.