The above results showed that IMD deficiency in VSMCs or Ang II treatment significantly increased blood pressure and aggravated vascular fibrosis and prosenescent factor expression in arterial media, and IMD deficiency in VSMCs significantly promoted Ang II-induced changes, suggesting that IMD deficiency may aggravate vascular senescent phenotype transition and promote the elevation in blood pressure and myocardial hypertrophy. The gene discussed is AGT; the disease is cardiac hypertrophy.