AKT1 and Parkinson disease: Furthermore, in PD zebrafish models, Calendula extracts nearly restored the morphology and density of dopaminergic neurons, an effect attributed to bioactive compounds such as 3,4-dicaffeoylquinic acid, isorhamnetin 3-O-glucoside, and calenduloside E. These molecules appear to act by activating the PI3K/Akt pathway and inhibiting ERK/Hsp90α signaling, mechanisms that support both neuronal protection and the improvement of cognitive and anxiolytic behaviors [40,41].