HVCN1 and cancer: Without being exhaustive, the role of Hv1 has been highlighted in cancer cell migration and proliferation, cell survival and apoptosis [10,21], sustained calcium entry [56], neutrophil migration and superoxide production [56], sperm capacitation and motility [17], participation in optimal B-cell receptor signaling and redox control in human B lymphocytes [19], and regulation of insulin secretion [16].