The findings demonstrate that hybrid compounds derived from curcumin and resveratrol can overcome pharmacokinetic limitations compared to natural polyphenols alone, while simultaneously suppressing the AKT1, MAPK, and STAT3 signaling pathways, which play crucial roles in apoptosis resistance, proliferation, and metastasis of cancer cells, thereby representing promising multi-target anticancer agents. This evidence concerns the gene AKT1 and cancer.