For instance, APS impeded O-GlcNAc synthesis by decreasing OGT and augmenting OGA levels in doxorubicin (Dox)-treated Hep3B hepatocellular carcinoma (HCC) cell, leading to exacerbated Dox-induced ER stress, as evidenced by elevated CHOP expression. The gene discussed is OGT; the disease is hepatocellular carcinoma.