In the gastric adenocarcinoma cell lines AGS, SNU-1, SNU-5, and SNU-16, ONC201 significantly increased DR5 expression and sensitized cells to recombinant human TRAIL (rhTRAIL) or its PEGylated trimeric form, TLY012, resulting in strong activation of the extrinsic apoptotic pathway via caspase-8 and -3 [24]. Here, CASP8 is linked to gastric adenocarcinoma.