In a landmark study, ClpP was identified among a subset of deregulated mitochondrial enzymes, alongside cytochrome c oxidase subunit 5A (COX5A) and enoyl-CoA hydratase 1 (ECH1), suggesting impairments in redox homeostasis, mitochondrial protein quality control, and metabolic rewiring in tumor cells [40]. Here, CLPP is linked to neoplasm.