Hyperactivation of ClpP by ONC201 or its analogs ONC206/ONC212 induces unregulated proteolysis of mitochondrial respiratory complexes, leading to ATP depletion, increased ROS, and apoptosis of AML cells, including TP53-mutant subtypes, without harming normal hematopoietic progenitors [9]. Here, TP53 is linked to acute myeloid leukemia.