It was confirmed that Sch B could specifically activate PPARγ as the core regulatory target to regulate the expression of downstream lipid metabolism and apoptosis-related genes, improving lipid metabolism disorders and inhibit cell apoptosis in OA+PA-induced MAFLD cell models, which may provide more direct and comprehensive experimental evidence for the interaction between Sch B and PPARγ, as well as the core regulatory role of PPARγ. This evidence concerns the gene PPARG and Disorder of lipid metabolism.