Rosmarinic acid, one of the major compounds of Ec, has been shown to restore insulin-stimulated glucose uptake in muscle cells exposed to palmitate, although it has also been documented to exert a negative impact on the Akt signaling pathway, showing a potential inhibitory effect on the proliferation and invasion of hepatocellular carcinoma cells [27,40]. Here, AKT1 is linked to hepatocellular carcinoma.