In addition, anti-dsDNA titers were uniformly high across the cohort, limiting reliable assessment of their variability; however, the observed association between anti-dsDNA and IP-10 may reflect cytokine-driven bystander activation of autoreactive B cells, as previously proposed in lupus immunopathology [28,31]. The gene discussed is CXCL10; the disease is systemic lupus erythematosus.