To identify the potential modulators of TNFAIP3 (A20), a ubiquitin-editing enzyme critical for the regulation of NF-κB signaling, molecular docking studies were performed against its ovarian tumor (OTU) domain (PDB ID: 2VFJ), which mediates K63-linked deubiquitination of substrates, such as RIP1 and TRAF6. The gene discussed is NFKB1; the disease is ovarian neoplasm.