IRF1 and neoplasm: PPI network analysis of the DEGs revealed enrichment in the following modules: anti-inflammatory and immunosuppression (e.g., IL10 and TNFAIP3), pro-inflammatory and immune cell activation (e.g., IL7R, C5AR1, FPR1 and LYN), chemokines and cell migration (e.g., CXCR4 and CCR7), transcriptional regulation and signal transduction (e.g., IRF1, NFKBIA and HIF1A), tumor suppression and cell cycle regulation (e.g., PTEN and PTGS2), metabolism and lipid transport (e.g., SCARB1), and cytoskeleton and cell motility (e.g., PLEK).