SOX2 and familial pancreatic carcinoma: Importantly, beyond its pro-apoptotic effect, A. europaea hydroethanolic aerial parts’ extract and its bioactive constituents—including flavonoids, polyphenol-rich fractions, and saponins—were also found to downregulate key markers of cancer stemness, such as Oct-4 and Nanog proteins, as well as CD133 and Sox2 mRNA, in a dose-dependent manner in pancreatic cancer cell lines [22].