PIEZO1 and channelopathy: It is important to note again that our earlier reanalysis of the potential pathogenic gene variants from the same ALS cohort confirmed the absence of pathogenic variants of PIEZO2 and PIEZO1, hence substantiating that the proposed irreversible Piezo2 channelopathy is acquired and not inherited [7], as theorized by the non-contact dying-back injury mechanism theory of ALS [6].