Upon closer analysis of the KCNK16 gene, in which we identified a novel stop-gain variant (c.502C>T; p.Q168*), we detected another KCNK16 stop-gain variant (c.278G>A; p.W93*) in exon 2 of the gene in the project MinD database, which shows an increased genomic burden among ALS patients. The gene discussed is KCNK16; the disease is amyotrophic lateral sclerosis.