However, when Piezo2 channelopathy may become irreversible in ALS, the activated NF-κB pathway by TLR4/Myd88 signaling keeps on propelling the neuroinflammation in the CNS with non-resolving progressive impairment of the proprioceptive circuitry [77]. Here, NFKB1 is linked to amyotrophic lateral sclerosis.