TPPP and multiple system atrophy: Specifically, in MSA αSyn, along with the oligodendroglial-specific phosphoprotein tubulin-polymerization promoting protein TPPP/p25α [5], deposit mostly within the cytoplasm of oligodendrocytes, the myelinating cells of the central nervous system (CNS), leading to the composition of glial cytoplasmic inclusions (GCIs) [6,7].