CTSD and multiple system atrophy: The authors surmised that since different strains of αSyn are responsible for the distinct phenotypes of α-Synucleinopathies, it is possible that the low co-localization of CTSD with pathological conformers of αSyn detected in MSA, in contrast to PD cases, may be due to the high vulnerability of oligodendrocytes in the MSA-related αSyn strains [71].