In this model of HFpEF induced by a high-fat diet and L-NAME, which produced obesity, glucose intolerance, and hypertension, myocardial resident reparative CCR2−MHCII− macrophages decreased and proinflammatory CCR2+MHCII+ macrophages increased during preclinical stages. This evidence concerns the gene CCR2 and obesity due to melanocortin 4 receptor deficiency.