The most potent dual inhibitor 3c, which can be taken as a hit for future molecular optimization studies and candidate for further AD-related targeted biochemical and biophysical assays (e.g., biometal-chelating, antioxidant, β-amyloid aggregation), showed a good water solubility at pH 7.4 (1.8 mol·L−1; fiftyfold more soluble than calculated). The gene discussed is PPIB; the disease is Alzheimer disease.