From an evolutionary perspective it has been speculated that, during the evolution of species, certain HLA class I alleles less prone to mutations (e.g., HLA-B*27, HLA-B*51, HLA-B*57:01 and HLA-C*06, the ones exhibiting the strongest protective effect against HIV infections) have been selected in the course of evolution by devastating epidemics as their immunodominant peptides generated stronger immune responses. Here, HLA-C is linked to HIV infectious disease.