HLA-B and HIV infectious disease: From an evolutionary perspective it has been speculated that, during the evolution of species, certain HLA class I alleles less prone to mutations (e.g., HLA-B*27, HLA-B*51, HLA-B*57:01 and HLA-C*06, the ones exhibiting the strongest protective effect against HIV infections) have been selected in the course of evolution by devastating epidemics as their immunodominant peptides generated stronger immune responses.