Another study, authored by Zaryczańska et al., included 191 AD patients and 168 healthy people, and also found no difference in serum level of IL-33 between AD patients and healthy subjects, and no association was found between serum IL-33 level and pruritus intensity, IgE level, or SCORAD index, which is used to assess the severity of AD [81]. The gene discussed is IL33; the disease is Alzheimer disease.