However, this statement needs to be examined further, as high IL-31 serum level was associated with higher National Institutes of Health Stroke Scale (NIHSS) score, hemorrhage volume, and poor prognosis [89], while a high serum level of IL-33 was a marker of good prognosis, and it was negatively correlated with baseline NIHSS score and hemorrhage volume [90]. This evidence concerns the gene IL31 and hemorrhage.