Herold et al. [46] showed that metabolic preconditioning of adipofascial flaps with insulin and glucocorticoids improved graft survival, reinforcing the concept that fascia may also harbor pathological progenitors, as demonstrated in Dupuytren’s disease, when mesenchymal stem cells contribute to fibrotic remodeling. The gene discussed is INS; the disease is Dupuytren Contracture.