Notably, Wu and colleagues showed in a murine HCC model that HMMR knockout suppresses tumor growth and enhances macrophage-mediated phagocytosis; mechanistically, RHAMM assembles a cytoplasmic complex that activates (focal adhesion kinase) FAK-SRC-NF-κB signaling to sustain CD47-mediated anti-phagocytic signaling independently of CD44. The gene discussed is HMMR; the disease is hepatocellular carcinoma.