Subsequent studies have corroborated these findings in various models of chronic inflammation, including liver disease, where HA-CD44 interactions, either alone or in cooperation with adhesion molecules such as E-selectin and intracellular adhesion molecule-1 (ICAM-1), facilitate the infiltration and retention of effector T cells within inflamed tissues [18,68,69] (Figure 2). The gene discussed is CD44; the disease is liver disorder.