Notably, the treatment based on the combination of hesperidin and Orlistat was more efficient than the treatment with Orlistat alone in increasing the HDL-cholesterol levels and in decreasing the values of LDL-cholesterol, TNF-α, and the HOMA-IR index, indicating that this flavonoid increased the anti-obesity effects of the drug Orlistat, improving both the glycemic and lipid profiles in vivo [113]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.