TNF and Hyperglycemia: The same study showed that the treatment with this flavonoid significantly decreased the levels of the pro-inflammatory markers TNF-α and MCP-1 and of the lipogenic markers FAS and SREBP1, induced an increase in p-Akt levels, and inhibited the molecular pathway TNF-α/c-Jun N-terminal kinase 1 (JNK1)/Forkhead box protein O1 (FoxO1)/PEPCK, hindering the activation of the gluconeogenesis process to counteract, in an in vivo experimental model, the detrimental effects of hyperglycemia [99].