IRS1 and Insulin resistance: Of note, it was reported that the flavonoid EGCG can increase, in vivo, the levels of p-IRS-1 and GLUT4 and that the flavonoid cyanidin can increase, in an in vivo experimental model, the p-Akt levels, showing that these flavonoid activate the insulin signalling pathway to inhibit the insulin resistance mechanisms [97,98,99] and suggesting that these phytochemicals could be combined with Liraglutide, Semaglutide, and Tirzepatide to improve their efficacy.