FAS and obesity due to melanocortin 4 receptor deficiency: Furthermore, the studies showing that the flavonoids nobiletin and cyanidin can decrease FAS levels in in vitro and in vivo models, respectively [12,99], and that the flavanone naringenin can decrease triglyceride levels and improve the lipid profile in clinical trials [102,103] suggest that these natural molecules could be combined with the drug Orlistat to improve its anti-obesity effects.