It was shown that hypomethylation of ADIPOQ, IRS1, and PI3KR1 genes was associated with a decrease in BMI and the inhibition of insulin resistance, while the hypermethylation of TNF and IL-6 genes was associated with a decrease in inflammatory markers and, consequently, with the inhibition of the molecular pathways of obesity [52]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.