Of note, in the context of diabesity, the flavonoid EGCG can decrease body weight, adipose mass, cholesterol, and triglyceride levels and, in addition, can inhibit the mechanisms of insulin resistance, improve glucose metabolism, and increase the levels of p-AMPK, p-IRS-1, and GLUT4 in vivo to counteract the detrimental effects of T2DM [97]. Here, IRS1 is linked to Insulin resistance.