GLP1R and obesity due to melanocortin 4 receptor deficiency: Notably, the drugs Cotadutide, Survodutide, Efinopegdutide, Pemvidutide, and Bamadutide have been developed as GLP1-R/glucagon receptor agonists and can increase energy expenditure and decrease food intake and hepatic lipogenesis, counteracting the detrimental effects of obesity [112].