In MITF-high early-stage melanoma, MITF promotes proliferation and limits invasiveness by activating the mechanistic target of rapamycin complex 1 (mTORC1), which sequesters transcription factor E3 (TFE3) in the cytoplasm and directs it for lysosomal degradation, reducing its pro-invasive effects [77]. This evidence concerns the gene TFE3 and melanoma.