Differential plasma levels between patients with preneoplasia and healthy subjects were also observed for ATAD3B, IGFALS, Junction Plakoglobin (JUP), LBP, and MAN2A1 (Figure 4), which, along with Arginase-1 (ARG1), CA2, HPT, and KRT14, are also differentially abundant between GC patients and healthy individuals. The gene discussed is JUP; the disease is gastric cancer.