However, a parallel univariate GLM analysis including the anatomical site of thrombus development demonstrated a highly significant three-way interaction between PAI-1 4G homozygosity (4G/4G), ACE D homozygosity (D/D), and thrombosis site (cerebral vs. other), which notably affects miRNA expression (p = 0.006). This evidence concerns the gene ACE and deep vein thrombosis.