It has been demonstrated that increased PAI-1 levels ultimately lead to diminished fibrinolytic activity and a hypercoagulable state, therefore skyrocketing the risk of both venous and arterial thrombosis, while the generation of thrombin itself acts as an inducer of additional PAI-1 secretion [13,15,16,17,20]. This evidence concerns the gene SERPINE1 and Arterial thrombosis.