MTHFR and Rare hereditary thrombophilia: Inherited thrombophilia is considered a solid risk factor in pediatric thrombosis and includes the presence of genetic variants causing functional or quantitative imbalances in factors involved in hemostasis and fibrinolysis, such as factor V (FV) Leiden, prothrombin (PTH), methylenetetrahydrofolate reductase (MTHFR), plasminogen activator inhibitor-1 (PAI-1), and angiotensin-converting enzyme (ACE) [11,14].