Notably, biallelic mutations in certain FA pathway genes, such as FANCS/BRCA1, FANCO/RAD51C, FANCR/RAD51, and FANCM can cause an FA-like disorder that shares the cancer predisposition of classical FA and, in some cases, the associated developmental abnormalities, but lacks bone marrow failure [58]. This evidence concerns the gene BRCA1 and cancer.