The regulation of the STAT3 gene during viral infection involves twenty-four miRNAs, including let-7 family miRNAs, miR-181a-5p, miR-29a-3p, miR-29b-3p, miR-98-5p, miR-125a-5p, miR-296-5p, miR-340-5p, miR-370-3p, miR-4458, miR-4500, miR-4516, miR-665, miR-6807-5p, miR-6845-3p, miR-6893-3p, miR-92a-3p and others. The gene discussed is STAT3; the disease is viral infectious disease.