Continuous infusion of ELABELA in mice subjected to pressure overload by transverse aortic constriction (TAC) reduced mRNA expression of genes associated with cardiac hypertrophy, such as BNP (brain natriuretic peptide) and β-Myhc (β-myosin heavy chain), and histological analysis revealed that ELA treatment reduced the area of cardiac fibrosis. Here, NPPB is linked to cardiac hypertrophy.