Studies investigating the expression and splicing patterns of Alzheimer’s disease risk genes in both brain and cell models have elucidated the potential pathological roles of these genes, including Frmd4a, and triggering receptor expressed on myeloid cells 2 (TREM2) and clusterin, the typical Alzheimer’s disease risk gene products [28,29], in disease pathogenesis by examining their transcriptional activities [30]. The gene discussed is CLU; the disease is early-onset autosomal dominant Alzheimer disease.