Regarding anti-inflammatory cytokines, IL-4 exerts antitumor effects by promoting macrophage and eosinophil infiltration, enhancing the cytotoxic activity of TNF-α, showing additive antiproliferative effects with agents such as TGF-β1 and tamoxifen, and directly inducing apoptosis in breast cancer cell lines [99]. This evidence concerns the gene TGFB1 and breast carcinoma.