Administration of Bifidobacterium supplements, together with a dietary fiber, to obese or overweight participants, resulted in changes in zonulin that significantly correlated with changes in trunk fat mass [93] LBP is linked to old age, obesity and metabolic syndrome, while sCD14 correlates with age but not with metabolic markers [94,95]. This evidence concerns the gene HP and obesity due to melanocortin 4 receptor deficiency.