Since the highest expression of the Drd2:Drd3 heteromer in the colonic mucosa was observed in Treg cells, which further increases upon inflammation, and both Drd2 and Drd3 exert an important regulatory effect on the suppressive activity and colonic tropism of Treg in inflammatory conditions, we next addressed the relevance of the Drd2:Drd3 heteromer in the suppressive activity and colonic tropism of Treg in gut inflammation. Here, DRD3 is linked to inflammatory response.