To evaluate whether HY7718 affects the expression of renal inflammation-related genes in adenine-induced CKD mice, we measured the mRNA levels of these genes (Tnf, Il-6, Il-1β and Ccl2), including those belonging to the NFκB/TLR signaling pathway (Tlr4 and Nfκb1). This evidence concerns the gene TLR4 and chronic kidney disease.