The heatmap of the surface receptor against the extracellular ligand indicates that binding affinity of the extracellular fibronectin ligand (PDB ID: 3VI4) is higher for most surface receptors (PDB ID: 3MJG, 1KTZ, 1IVO, 1SHY, 1IAR, 1SUV, 5T89, 1EVT, 3VI4, 2I9B), as shown in Figure 4A. Similarly, the analysis of surface receptors vs. surface receptors is presented in Figure 4B. The result highlights the interaction between ligands within the cancer micro-environment and surface receptor–proteins’ interactions in glioblastoma cancer cells. The gene discussed is FN1; the disease is cancer.