Together with increased erythropoiesis (mediated in part by increased erythropoietin, which in turn increases erythroferrone, an inhibitor of hepcidin transcription [18]), this iron deficiency suppresses the hepatic production of the hormone hepcidin, an inhibitor of the iron-export protein ferroportin 1 [19]. The gene discussed is HAMP; the disease is Iron deficiency anemia.