Mechanistically, recent computational and wet-lab studies have linked miR-106b-5p activity to cell cycle regulators and pathways involved in DNA damage response and apoptosis—consistent with its context-dependent tumor-suppressor or oncogenic behavior observed in earlier reports—suggesting that its prognostic value may depend on coexisting molecular features (e.g., TP53 status, transcriptomic subtype) and tumor microenvironmental cues [45,46]. Here, TP53 is linked to neoplasm.