Regarding the pathologies that may compromise blood circulation, a recent investigation claimed that STC1 reduces the effects associated with myocardial ischemia–reperfusion injury [35] and, further, the activation of PAR1 leads to STC1 upregulation, which may act as cytoprotection in the case of thromboinflammatory injury [36]. The gene discussed is STC1; the disease is myocardial ischemia.