For example, splicing factor genes such as serine/arginine-rich splicing factor 2 (SRSF2) and zinc finger CCCH-type, RNA-binding motif and serine/arginine-rich 2 (ZRSR2) are frequently mutated in myeloid neoplasms [37], triggering specific splicing abnormalities that result in aberrant mRNA isoforms translated into tumor-specific neoantigens. The gene discussed is ZRSR2; the disease is myeloid neoplasm.