By further concentrating on the essential signaling pathways that are closely linked to B-ALL disease progression—namely, CD30, T cell immunoglobulin and ITIM domain (TIGIT), B- and T-lymphocyte attenuator (BTLA), Laminin, CD48, type II interferon (IFN-II), thrombospondin (THBS), and CD70—we constructed their intercellular interaction networks specific to the group D (Figure 7C–L) to elucidate the distinctive intercellular interaction patterns characteristic of this B-ALL group. The gene discussed is CD48; the disease is precursor B-cell acute lymphoblastic leukemia.