UHRF1 and acute lymphoblastic leukemia: Furthermore, studies indicate that epigenetic remodeling can regulate glycolysis-related genes, such as the ubiquitin-like with PHD and ring finger domains 1 (UHRF1) protein, which modulates the expression of glycolytic genes through epigenetic mechanisms, thereby promoting aerobic glycolysis in B-ALL cells and providing energy support for cell proliferation [48].