The AA genotype for rs4648090 [G/A] of NFKB1 (p = 0.022) and the TT + TC cluster for rs317155 [T/C] of the NOX4 gene (p = 0.008) were significantly associated with the highest expression of the proteins encoded by these genes in the cohort of patients affected by the second wave of COVID-19 (Table 4); however, before the Bonferroni correction (p < 0.001), this association was lost. This evidence concerns the gene NOX4 and COVID-19.