ND GBM pre-surgery saliva (NDT0) showed the exclusive characterization of peptide fragments of CDA, HOPX, FABP5, WIPF3, VOPP1, AHNAK, and DAZAP1 proteins, which, to the best of our knowledge, have not been previously identified in relation to GBM tumor. This evidence concerns the gene VOPP1 and glioblastoma.