Together, these results consistently demonstrate that p38-MAPK and NF-κB signaling pathways play a key role in regulating miR-125b-5p expression and its downstream target MMP-2 in SHP-77 lung cancer cells, whereas ERK-MAPK and JNK-MAPK pathways appear to be non-contributory. This evidence concerns the gene NFKB1 and lung cancer.