We determine whether the modulation of hsa-miR-125b-5p and MMP-2 by S100A4-RAGE signaling in human lung cancer cells (A549) involves the activation of mitogen-activated protein kinases (MAPKs), including p38-MAPK, Jun kinase (JNK/SAPK), and extracellular signal-regulated kinase (ERK) pathways. Here, MMP2 is linked to lung cancer.