Similarly, miR-566 and miR-150 downregulate pVHL expression, promoting the HIF, VEGF, and matrix metalloproteinase (MMP-2 and MMP-9), thereby enhancing glioma proliferation, migration, invasiveness, glucose metabolism, and resistance to apoptosis [84,85] (Figure 2, left side). The gene discussed is VHL; the disease is central nervous system cancer.