Thus, inducing HIF-1α-mediated expression of angiogenic growth factors such as VEGF-A, basic fibroblast growth factor (bFGF), placenta growth factor (PlGF), and platelet-derived growth factor (PDGF) results in aberrant vascularization and tumor hypoxia, leading to GBM progression [93]. This evidence concerns the gene VEGFA and glioblastoma.