Also, inhibitor of DNA binding 2 (ID2) is a protein mainly expressed in response to stress such as hypoxia; drives the adaptive cellular response to metabolic stress, suppressing ROS production from mitochondria, reducing mitochondrial damage, and promoting tumor cell survival during glucose deprivation; and has also been involved in GBM-associated pVHL suppression. The gene discussed is ID2; the disease is glioblastoma.