Future research should seek to clarify the mechanistic relationship between neutropenia and IL-6 dysregulation—specifically, whether IL-6 elevation represents a compensatory response to neutrophil depletion or underlying disease pathophysiology, the contribution of non-neutrophil immune cells to IL-6 production during neutropenia, and the longitudinal dynamics of IL-6 as neutrophil counts recover. The gene discussed is IL6; the disease is Decreased total neutrophil count.