We defined two broad phenotypes: a hyperinflammatory phenotype (IL-6 ≥ 100 pg/mL, predicted mortality probability > 40%) characterized by sepsis, prior allogeneic HSCT, mechanical ventilation, vasopressor requirement, and elevated inflammatory markers other than IL-6 (CRP, PCT, lactate, and cortisol), and a non-hyperinflammatory phenotype with lower disease burden. The gene discussed is CRP; the disease is Sepsis.