Peripheral cells (lymphoblasts) isolated from GRN mutation-carrier (c.709-1G > A) with TDP43-positive FTD patients showed that GRN haploinsufficiency stimulated NFkappaB signaling and overactivated Wnt5a signaling, leading to increased intracellular Wnt5a levels and Wnt5a secretion. This evidence concerns the gene TARDBP and frontotemporal dementia.