Other immunosuppressors are Tregs and tumor-associated (M2) macrophages, which, like MDSCs, release immunosuppressive cytokines such as IL-10 and transforming growth factor beta (TGF-β) and increase programmed death ligand 1 (PD-L1) expression in tumor cells, resulting in immune evasion from CTL attacks [24]. The gene discussed is CD274; the disease is neoplasm.