In the TN subtype, TILs, low NLR/high TIL density, systemic immune mediators, high TIL levels/PD-L1 (chemotherapy + ICI), CD8/FOXP3 ratio, TIL level changes, high TCR clonality, PD-L1, high CD3/CD68 ratio, T cell–tumor cell proximity, T cell proximity, PD-L1, decreased TIL levels and PD-L1, high pre-NAC TIL levels, CD8/CD4 ratio, post-NAC CD4 levels, and high apoptosis scores were associated with pCR. The gene discussed is CD8A; the disease is neoplasm.