CALR and cancer: ICD, which improves the low immunogenicity of breast and other cancer cells, is characterized by spatiotemporal surface rearrangements of danger molecules and the simultaneous occurrence of damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), adenosine triphosphate (ATP), high mobility group box 1 (HMGB1), and annexin A1 (ANXA1) [16,17].