In spite of this aspect, it is also worth mentioning that if we compare CGRP with other peptides involved in migraine pathophysiology, such as vasoactive intestinal peptide (VIP) or pituitary adenylate cyclase-activating polypeptide (PACAP) [48,49], CGRP has a relatively long half-life, which might account for its prolonged action in migraine [50]. Here, CALCA is linked to migraine disorder.