The activation of the NF-κB and MAPK signaling pathways leads to excessive innate immune response, leading to acute and chronic inflammatory diseases, such as neurodegenerative disorders [11], inflammatory bowel disease (IBD) [12], chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), and cancer [13]. This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.