The genomic proximity of JTB to the gene encoding cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4) [14], another AR-regulated gene involved in cell proliferation and endoplasmic reticulum (ER) stress response [15], supports the hypothesis that CREB3L4 and JTB may be co-regulated by AR and potentially contribute to tumor progression. The gene discussed is CREB3L4; the disease is neoplasm.